Protein Kinase C Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs
نویسندگان
چکیده
Audrey K. O’Neill, Lisa L. Gallegos, Verline Justilien, Erin L. Garcia , Michael Leitges**, Alan P. Fields, Randy A. Hall , and Alexandra C. Newton From the Department of Pharmacology and Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093, the Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, the Department of Pharmacology, Emory University, Atlanta, Georgia 30322, and the **Biotechnology Centre of Oslo, University of Oslo, 0317 Oslo, Norway
منابع مشابه
Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1).
Protein scaffolds maintain precision in kinase signaling by coordinating kinases with components of specific signaling pathways. Such spatial segregation is particularly important in allowing specificity of signaling mediated by the 10-member family of protein kinase C (PKC) isozymes. Here we identified a novel interaction between PKCα and the Discs large homolog (DLG) family of scaffolds that ...
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تاریخ انتشار 2011